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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK12
All Species:
15.76
Human Site:
S440
Identified Species:
38.52
UniProt:
Q9NYV4
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NYV4
NP_055898.1
1490
164155
S440
S
S
V
E
A
K
D
S
G
L
E
S
K
K
L
Chimpanzee
Pan troglodytes
XP_001139939
1512
164915
R432
R
H
R
L
S
R
S
R
S
R
H
S
S
I
S
Rhesus Macaque
Macaca mulatta
XP_001088594
1490
164086
S440
S
S
V
E
A
K
D
S
G
L
E
S
K
K
L
Dog
Lupus familis
XP_548147
1490
164467
S440
S
L
V
E
A
K
D
S
G
L
E
S
K
K
L
Cat
Felis silvestris
Mouse
Mus musculus
Q14AX6
1484
163663
S437
E
K
L
E
V
K
E
S
G
L
E
S
K
K
L
Rat
Rattus norvegicus
Q3MJK5
1484
163772
S437
E
K
F
E
V
K
E
S
G
L
E
S
K
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_687417
1286
141523
F314
S
P
Y
E
Q
G
E
F
A
G
S
P
Y
G
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_397595
1492
167042
K492
S
T
R
K
H
K
S
K
S
P
R
P
S
R
I
Nematode Worm
Caenorhab. elegans
P46551
730
82410
Sea Urchin
Strong. purpuratus
XP_789337
1264
139419
A292
Y
R
K
K
T
V
Q
A
A
K
A
K
V
V
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
42.3
98.4
95.1
N.A.
91.1
91.7
N.A.
N.A.
N.A.
N.A.
39.1
N.A.
N.A.
36
27.6
35.7
Protein Similarity:
100
54.2
99.1
96.9
N.A.
94.7
95
N.A.
N.A.
N.A.
N.A.
50.4
N.A.
N.A.
51.7
36
49.5
P-Site Identity:
100
6.6
100
93.3
N.A.
66.6
66.6
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
13.3
0
0
P-Site Similarity:
100
20
100
93.3
N.A.
80
73.3
N.A.
N.A.
N.A.
N.A.
20
N.A.
N.A.
40
0
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
30
0
0
10
20
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
30
0
0
0
0
0
0
0
0
% D
% Glu:
20
0
0
60
0
0
30
0
0
0
50
0
0
0
0
% E
% Phe:
0
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
10
0
0
50
10
0
0
0
10
0
% G
% His:
0
10
0
0
10
0
0
0
0
0
10
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
10
% I
% Lys:
0
20
10
20
0
60
0
10
0
10
0
10
50
50
10
% K
% Leu:
0
10
10
10
0
0
0
0
0
50
0
0
0
0
50
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
10
0
0
0
0
0
0
0
10
0
20
0
0
0
% P
% Gln:
0
0
0
0
10
0
10
0
0
0
0
0
0
0
10
% Q
% Arg:
10
10
20
0
0
10
0
10
0
10
10
0
0
10
0
% R
% Ser:
50
20
0
0
10
0
20
50
20
0
10
60
20
0
10
% S
% Thr:
0
10
0
0
10
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
30
0
20
10
0
0
0
0
0
0
10
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
10
0
0
0
0
0
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _